A modern approach to treatment, as well as medical research, requires a lot of data about a patient for a better outcome. More profound knowledge about the human body, genetic, phenotypic, or psychosocial characteristics could ensure precise identification of patient risk factors, early diagnosis of a disease, or treatment targeting. One of our clients decided to use medical data to build patient similarity networks to define the safety of hydroxychloroquine, a drug to treat rheumatoid arthritis. We determined whether it is safe to use hydroxychloroquine (alone and in combination with azithromycin) via building patient similarity networks.
The patient similarity is a way to use medical data sets to integrate multiple data types to facilitate medical decision-making. While individualized data-driven clinical analysis is still developing, patient similarity networks can facilitate research. Moreover, patient similarity solutions are crucial to innovative targeted drug trials, overcoming drug resistance, and combining therapies. Patient similarity networks development is crucial in the case of hydroxychloroquine, as it has got negative coverage due to adverse events when treating patients with COVID-19 pneumonia for emergency use. Our client wanted us to define whether hydroxychloroquine is safe for patients with rheumatoid arthritis (at the age of 18 years or older).
As a result, we defined that hydroxychloroquine treatment is safe for patients with rheumatoid arthritis in the short term but might be associated with cardiovascular mortality in the long term.
Hydroxychloroquine plus azithromycin in the short term poses a risk of cardiovascular mortality and heart failure. So, our study shows that hydroxychloroquine treatment should be assigned carefully.